Association analysis of ERCC5 gene polymorphisms with risk of breast cancer in Han women of northwest China
| Autor: | Haitao Wang, Gongjian Zhu, Suisheng Yang, Qing-Rong Hu, Tao Wang, Yanze Du, Haixiang Su, Xuezhong Chen, Hongyun Guo, Xiaorong Bai |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
0301 basic medicine Oncology China medicine.medical_specialty DNA repair Population Breast Neoplasms Single-nucleotide polymorphism Bioinformatics Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Breast cancer Asian People Polymorphism (computer science) Internal medicine Genotype Humans Medicine Genetic Predisposition to Disease Pharmacology (medical) Radiology Nuclear Medicine and imaging education Genetic association education.field_of_study business.industry Case-control study Nuclear Proteins General Medicine Middle Aged Endonucleases medicine.disease DNA-Binding Proteins Genetics Population 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female business Transcription Factors |
| Zdroj: | Breast Cancer. 23:479-485 |
| ISSN: | 1880-4233 1340-6868 |
| Popis: | ERCC5 plays an important role in DNA damage repair. Mutations in it will lead to DNA repair defects and genomic instability. Its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity and affect cancer susceptibility. This study aims to evaluate the association between SNPs in ERCC5 and breast cancer susceptibility in Han women subjects genetically from northwest China. A total of 101 breast cancer patients and 101 healthy controls provided blood samples for analysis of ERCC5 rs17655 and rs751402 genotypes. After adjusting covariates, rs751402 homozygote AA and heterozygote AG were found to confer statistically significant protections (OR 0.052, 95 % CI 0.006–0.411, P = 0.005; OR 0.145, 95 % CI 0.067–0.315, P |
| Databáze: | OpenAIRE |
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