Convergent Evolution of Hydrogenosomes from Mitochondria by Gene Transfer and Loss
| Autor: | Thijs J. G. Ettema, T. Martin Embley, William H Lewis, Kacper M Sendra, Anders E. Lind, Robert P. Hirt, Tom A. Williams, Genoveva F. Esteban, Henning Onsbring |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Mitochondrial DNA
Gene Transfer Horizontal Hydrogenosome Genomics microbial eukaryotes Biology Mitochondrion Microbiology Evolution Molecular Evolutionsbiologi 03 medical and health sciences Microbiologie Convergent evolution evolution Genetics genomics Anaerobiosis Ciliophora Molecular Biology Ecology Evolution Behavior and Systematics Phylogeny Discoveries 030304 developmental biology 0303 health sciences Evolutionary Biology WIMEK Sequence Analysis RNA Gene Expression Profiling 030302 biochemistry & molecular biology Biochemistry and Molecular Biology Sequence Analysis DNA biology.organism_classification anaerobic metabolism Aerobiosis Mitochondria mitochondria Evolutionary biology hydrogenosomes Proteome Horizontal gene transfer Genome Mitochondrial Biokemi och molekylärbiologi Archaea Hydrogen |
| Zdroj: | Molecular Biology and Evolution 37 (2020) 2 Molecular Biology and Evolution Molecular Biology and Evolution, 37(2), 524-539 Lewis, W, Lind, A, Sendra, K M, Onsbring, H, Williams, T, Esteban, G, Hirt, R P, Ettema, T J G & Embley, T M 2019, ' Convergent evolution of hydrogenosomes from mitochondria by gene transfer and loss ', Molecular Biology and Evolution . https://doi.org/10.1093/molbev/msz239 |
| ISSN: | 0737-4038 |
| DOI: | 10.1093/molbev/msz239 |
| Popis: | Hydrogenosomes are H2-producing mitochondrial homologs found in some anaerobic microbial eukaryotes that provide a rare intracellular niche for H2-utilizing endosymbiotic archaea. Among ciliates, anaerobic and aerobic lineages are interspersed, demonstrating that the switch to an anaerobic lifestyle with hydrogenosomes has occurred repeatedly and independently. To investigate the molecular details of this transition, we generated genomic and transcriptomic data sets from anaerobic ciliates representing three distinct lineages. Our data demonstrate that hydrogenosomes have evolved from ancestral mitochondria in each case and reveal different degrees of independent mitochondrial genome and proteome reductive evolution, including the first example of complete mitochondrial genome loss in ciliates. Intriguingly, the FeFe-hydrogenase used for generating H2 has a unique domain structure among eukaryotes and appears to have been present, potentially through a single lateral gene transfer from an unknown donor, in the common aerobic ancestor of all three lineages. The early acquisition and retention of FeFe-hydrogenase helps to explain the facility whereby mitochondrial function can be so radically modified within this diverse and ecologically important group of microbial eukaryotes. |
| Databáze: | OpenAIRE |
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