Association Between Statin Use Prior to Admission and Lower Coronavirus Disease 2019 (COVID-19) Severity in Patients With Cardiovascular Disease or Risk Factors
| Autor: | Misaki Hasegawa, Shunsuke Kuroda, Taishi Yonetsu, Takuya Kishi, Shingo Matsumoto, Takeshi Kitai, Kazuki Aihara, Issei Komuro, Sho Torii, Yuya Matsue, Takahide Sano, Ken-ichi Hirata, Yuji Ikari, Shun Kohsaka, Koichi Node |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Statin Databases Factual medicine.drug_class medicine.medical_treatment Comorbidity 030204 cardiovascular system & hematology Risk Assessment Severity of Illness Index 03 medical and health sciences Patient Admission 0302 clinical medicine Japan Internal medicine Diabetes mellitus Severity of illness medicine Extracorporeal membrane oxygenation Humans 030212 general & internal medicine Aged Dyslipidemias Retrospective Studies Aged 80 and over business.industry COVID-19 Retrospective cohort study General Medicine Odds ratio Middle Aged medicine.disease Cardiovascular Diseases Heart Disease Risk Factors Female Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine Risk assessment business |
| Zdroj: | Circulation Journal. 85:939-943 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-21-0087 |
| Popis: | BACKGROUND: Cardiovascular diseases and/or risk factors (CVDRF) have been reported as risk factors for severe coronavirus disease 2019 (COVID-19).MethodsâandâResults:In total, we selected 693 patients with CVDRF from the CLAVIS-COVID database of 1,518 cases in Japan. The mean age was 68 years (35% females). Statin use was reported by 31% patients at admission. Statin users exhibited lower incidence of extracorporeal membrane oxygenation (ECMO) insertion (1.4% vs. 4.6%, odds ratio [OR]: 0.295, P=0.037) and septic shock (1.4% vs. 6.5%, OR: 0.205, P=0.004) despite having more comorbidities such as diabetes mellitus. CONCLUSIONS: This study suggests the potential benefits of statins use against COVID-19. |
| Databáze: | OpenAIRE |
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