PROZ May Serve as a Prognostic Biomarker for Early Hepatocellular Carcinoma
| Autor: | Xiu-hua Pan, Xinyu Zhang, Li Bai, Yuhong Lan, Xiaocong Jiang, Ting Song |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fibrinogen-gamma chain
bioinformatics analysis Apolipoprotein B biology business.industry Protein Z International Journal of General Medicine hepatocellular carcinoma General Medicine medicine.disease digestive system diseases weighted gene coexpression network analysis APOA4 Hepatocellular carcinoma Gene expression biology.protein Cancer research Medicine Early Hepatocellular Carcinoma business Gene vitamin K-dependent protein Z Original Research |
| Zdroj: | International Journal of General Medicine |
| ISSN: | 1178-7074 |
| DOI: | 10.2147/ijgm.s311959 |
| Popis: | Xiaocong Jiang,1,* Ting Song,2,* Xiuhua Pan,1 Xinyu Zhang,1 Yuhong Lan,1 Li Bai1 1Department of Radiotherapy Oncology, Huizhou Central Peopleâs Hospital, Huizhou, 516001, Guangdong, Peopleâs Republic of China; 2Department of Hepatology, The Sixth Peopleâs Hospital of Qingdao, Qingdao, 266033, Shandong, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Li Bai Email bl_0067@126.comObjective: The occurrence and development of hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate potential diagnostic or prognostic markers for early HCC by applying bioinformatic analysis.Methods: The gene expression profiles of early HCC and normal tissues from a TCGA dataset were used to identify differentially expressed genes (DEGs) and then analysed by weighted gene coexpression network analysis. The integrated genes were selected to construct the proteinâprotein interaction (PPI) network and determine the hub genes. The prognostic impact of the hub genes was then analysed.Results: A total of 508 integrated genes were selected from the 615 DEGs and 8956 genes in the turquoise module. A PPI network was constructed, and the top 20 hub genes, including apolipoprotein A-IV (APOA4), fibrinogen gamma chain (FGG), vitamin K-dependent protein Z (PROZ), secreted phosphoprotein 24 (SPP2) and fetuin-B (FETUB), were identified. Only PROZ was significantly associated with the prognosis of early HCC.Conclusion: In this study, we demonstrated that the expression of PROZ was decreased in early HCC compared with normal liver controls, and low PROZ expression might result in poor overall survival of early HCC.Keywords: hepatocellular carcinoma, weighted gene coexpression network analysis, bioinformatics analysis, vitamin K-dependent protein Z |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|