Ionic Versus Nonionic Contrast Media Solvents Used with an Epirubicin-based Agent for Transarterial Chemoembolization of Hepatocellular Carcinoma
| Autor: | Chung Kuao Chou, Chi Hung Lin, Shih Chin Chang, Ching Yih Lin, Jyh Jou Chen, Reng Hong Wu, Wen Sheng Tzeng, Shun Chun Yang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Contrast Media Ionic Liquids Tumor response Gastroenterology Internal medicine medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Prospective Studies Chemoembolization Therapeutic Prospective cohort study Aged Epirubicin Antibiotics Antineoplastic medicine.diagnostic_test business.industry Liver Neoplasms Iodized Oil Magnetic resonance imaging Patient survival Middle Aged medicine.disease Magnetic Resonance Imaging Contrast medium Hepatocellular carcinoma Solvents Emulsions Female Radiology Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Vascular and Interventional Radiology. 19:342-350 |
| ISSN: | 1051-0443 |
| DOI: | 10.1016/j.jvir.2007.10.021 |
| Popis: | To compare the stability of epirubicin-iodized oil emulsions prepared with ionic or nonionic contrast medium and to compare the efficacy of these emulsions in a prospective, randomized, controlled trial of transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).Epirubicin-iodized oil emulsions prepared with ionic and nonionic contrast media was evaluated for stability with light microscopy and magnetic resonance imaging. One hundred ninety-seven patients with inoperable HCC were randomized to receive TACE with epirubicin, prepared either with ionic (control group, n = 99) or nonionic (experimental group, n = 98) contrast medium. Tumor response was graded according to iodized oil retention (grade 1 =90% retention, grade 2 = 50%-90% retention, and grade 3 =50% retention), as characterized with computed tomography. Survival probabilities were calculated with the Kaplan-Meier method.The epirubicin-iodized oil emulsions prepared with ionic contrast medium were less stable, exhibiting rapid separation of the oil and aqueous phases, compared with emulsions prepared with nonionic medium. Ninety-one patients in the control group and 87 in the experimental group underwent follow-up CT. Thirty-seven of the 91 patients in the control group (41%) had grade 1 tumors, 41 (45%) had grade 2 tumors, and 13 (14%) had grade 3 tumors. Forty-eight of the 87 patients in the experimental group (55%) had grade 1 tumors, 22 (25%) had grade 2 tumors, and 17 (20%) had grade 3 tumors. The number of patients with grade 1 tumors was significantly higher in the experimental group than in the control group (P = .02); however, there was no difference in patient survival (P = .94).Epirubicin-iodized oil emulsions prepared with nonionic contrast medium are more stable and are associated with lower tumor grade in patients with inoperable HCC. The choice of solvent, however, does not appear to have an effect on patient survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|