Chronic ambulatory electrocorticography findings preceding sudden death in epilepsy
| Autor: | Luke Edwards, Sandipan Pati, Kristen O. Riley, Jennifer L. DeWolfe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty medicine.diagnostic_test business.industry Case medicine.disease Unexpected death Sudden death Pathophysiology 03 medical and health sciences Epilepsy 030104 developmental biology 0302 clinical medicine Disease severity Ambulatory medicine Neurology (clinical) business Risk assessment Electrocorticography 030217 neurology & neurosurgery |
| Popis: | Sudden unexpected death in epilepsy (SUDEP) is the leading cause of premature mortality in patients with refractory epilepsy, but the underlying mechanisms and the predictors of patient risk remain an active area of research.1,2 At present, risk assessment is based on disease severity accrued over the preceding years, but how the risk changes with therapy and disease progression have been poorly understood.3 To establish the pathophysiology of SUDEP, studies have capitalized on experimental models4 and rare terminal events recorded in the epilepsy monitoring unit.5 In these settings, the seizures are either induced or precipitated by weaning off medications and hence the electrophysiologic changes should be validated with spontaneous seizures recorded over longer time scale. Here we report progressive electrophysiologic changes in ambulatory electrocorticography preceding sudden death in a 38-year-old, right-handed woman who had intractable bitemporal epilepsy. |
| Databáze: | OpenAIRE |
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