Gut microbiome and multiple sclerosis: New insights and perspective
| Autor: | Navid Shomali, Mohammad Esmaeil Amini, Solat Eslami, Arash Bakhshi, Shahram Torkamandi, Ramin Hosseinzadeh, Maryam Hemmatzadeh, Hamed Mohammadi, Farhad Babaie, Saeed Aslani, Somaye Rezaei |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Immunology Central nervous system Inflammation Disease Gut flora 03 medical and health sciences 0302 clinical medicine Immune system medicine Immunology and Allergy Animals Humans Pharmacology biology Bacteria business.industry Multiple sclerosis Human gastrointestinal tract Experimental autoimmune encephalomyelitis medicine.disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis medicine.symptom business |
| Zdroj: | International immunopharmacology. 88 |
| ISSN: | 1878-1705 |
| Popis: | The human gastrointestinal microbiota, also known as the gut microbiota living in the human gastrointestinal tract, has been shown to have a significant impact on several human disorders including rheumatoid arthritis, diabetes, obesity, and multiple sclerosis (MS). MS is an inflammatory disease characterized by the destruction of the spinal cord and nerve cells in the brain due to an attack of immune cells, causing a wide range of harmful symptoms related to inflammation in the central nervous system (CNS). Despite extensive studies on MS that have shown that many external and genetic factors are involved in its pathogenesis, the exact role of external factors in the pathophysiology of MS is still unclear. Recent studies on MS and experimental autoimmune encephalomyelitis (EAE), an animal model of encephalitis, have shown that intestinal microbiota may play a key role in the pathogenesis of MS. Therefore, modification of the intestinal microbiome could be a promising strategy for the future treatment of MS. In this study, the characteristics of intestinal microbiota, the relationship between intestine and brain despite the blood-brain barrier, various factors involved in intestinal microbiota modification, changes in intestinal microbial composition in MS, intestinal microbiome modification strategies, and possible use of intestinal microbiome and factors affecting it have been discussed. |
| Databáze: | OpenAIRE |
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