Plasma isocitrate dehydrogenase as a marker of centrilobular hepatic necrosis in patients with hyperthyroidism
| Autor: | Sung Ae Jung, Yung Sang Lee, Jeong A. Kim, Jung Weon Kim, Byung-Cheol Song, Dong Jin Suh, Won Beom Choi, Il Han Song, Young Hwa Chung, Young Kee Shong, Woo Young Chang |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Liver Cirrhosis Male endocrine system medicine.medical_specialty Thyroid Hormones Necrosis endocrine system diseases Thyroid Function Tests digestive system Thyroid function tests Hyperthyroidism Diagnosis Differential Hepatitis B Chronic Liver Function Tests Predictive Value of Tests Internal medicine medicine Humans Liver injury medicine.diagnostic_test business.industry Centrilobular necrosis Gastroenterology Alanine Transaminase Hepatitis C Hepatitis C Chronic medicine.disease digestive system diseases Isocitrate Dehydrogenase Endocrinology Isocitrate dehydrogenase Female medicine.symptom Thyroid function Liver function tests business hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Journal of clinical gastroenterology. 33(2) |
| ISSN: | 0192-0790 |
| Popis: | Isocitrate dehydrogenase (ICDH) may be useful for differentiating centrilobular from periportal necrosis in rats with liver injury. In this study, we assessed the usefulness of ICDH as a marker of centrilobular necrosis in patients with hyperthyroidism. Isocitrate dehydrogenase and alanine aminotransferase (ALT) activities were measured in the plasma of 56 patients with hyperthyroidism, 16 patients with chronic viral hepatitis (CVH), and 17 controls. Isocitrate dehydrogenase levels were higher in patients with hyperthyroidism than in those with CVH or in the controls (p < 0.01 and p < 0.001, respectively), even though ALT levels were higher in patients with CVH than in patients with hyperthyroidism (p < 0.01). Isocitrate dehydrogenase/ALT ratios were also higher in patients with hyperthyroidism than in those with CVH (p < 0.0001). Isocitrate dehydrogenase correlated to ALT levels in patients with hyperthyroidism or CVH (p < 0.05). In a patient with hyperthyroidism, ICDH levels decreased progressively to normal, and the ALT level and thyroid function were normalized. Thus, the plasma ICDH or ICDH/ALT ratio might be useful for differentiating centrilobular from periportal necrosis and for monitoring the degree of hepatic necrosis in patients with hyperthyroidism. |
| Databáze: | OpenAIRE |
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