The Role of Exosomes/Extracellular Vesicles in Neural Signal Transduction
| Autor: | Rikinari Hanayama, Hironori Kawahara |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Neurons Regeneration (biology) Central nervous system Pharmaceutical Science Neurodegenerative Diseases General Medicine Extracellular vesicle Biology Exosome Microvesicles 03 medical and health sciences Haematopoiesis Extracellular Vesicles 030104 developmental biology medicine.anatomical_structure Peripheral nervous system medicine Animals Humans Regeneration Signal transduction Neuroscience Signal Transduction |
| Zdroj: | Biologicalpharmaceutical bulletin. 41(8) |
| ISSN: | 1347-5215 |
| Popis: | Exosomes, in a broad sense extracellular vesicles (EVs), are secreted from several cells and also exist in cerebrospinal fluid (CSF); they contribute to signal transduction not only between neural cells but also among hematopoietic cells. In addition to the peripheral nervous system, the association of regeneration and EVs has also been reported in the central nervous system, for example, following a spinal cord injury. Furthermore, it has become clear that major causative factors of neurodegenerative diseases are transmitted by EVs; thus, EVs are involved in the pathogenesis of neurodegenerative diseases. In particular, we would like to outline the relationship between neurophysiology and neurological disorders centered on EV-mediated communication between neural and glial cells. |
| Databáze: | OpenAIRE |
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