Growth Differentiation Factor 11 is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
| Autor: | Amy J. Wagers, Alex Stewart, Matthew L. Steinhauser, Joseph Gannon, Nikolaos Psychogios, Danika Mei Po Khong, Christine M. Miller, Manisha Sinha, Adam J. Hartigan, Steven M. Jay, Claudia Dall'Osso, Mi-Jeong Kim, Pratyusha Yalamanchi, J Shadrach, Richard T. Lee, Francesco S. Loffredo, Thomas Serwold, Robert E. Gerszten, James R. Pancoast, Britta Singer |
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| Přispěvatelé: | Loffredo, Francesco S., Steinhauser, Matthew L., Jay, Steven M., Gannon, Joseph, Pancoast, James R., Yalamanchi, Pratyusha, Sinha, Manisha, Dall'Osso, Claudia, Khong, Danika, Shadrach, Jennifer L., Miller, Christine M., Singer, Britta S., Stewart, Alex, Psychogios, Nikolao, Gerszten, Robert E., Hartigan, Adam J., Kim, Mi-Jeong, Serwold, Thoma, Wagers, Amy J., Lee, Richard T. |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Aging Parabiosis Induced Pluripotent Stem Cells Blood Pressure Cardiomegaly Biology General Biochemistry Genetics and Molecular Biology Induced Pluripotent Stem Cell Article Muscle hypertrophy Mice Internal medicine medicine Myocyte Animals Humans Myocytes Cardiac Biochemistry Genetics and Molecular Biology (all) Animal Biochemistry Genetics and Molecular Biology(all) Bone Morphogenetic Protein Growth differentiation factor Forkhead Transcription Factors Forkhead Transcription Factor medicine.disease Mice Inbred C57BL Growth Differentiation Factors Endocrinology Blood pressure Growth Differentiation Factor Heart failure GDF11 Bone Morphogenetic Proteins Hypertrophy Left Ventricular Female Parabiosi Transforming growth factor Human |
| Zdroj: | BASE-Bielefeld Academic Search Engine |
| Popis: | SummaryThe most common form of heart failure occurs with normal systolic function and often involves cardiac hypertrophy in the elderly. To clarify the biological mechanisms that drive cardiac hypertrophy in aging, we tested the influence of circulating factors using heterochronic parabiosis, a surgical technique in which joining of animals of different ages leads to a shared circulation. After 4 weeks of exposure to the circulation of young mice, cardiac hypertrophy in old mice dramatically regressed, accompanied by reduced cardiomyocyte size and molecular remodeling. Reversal of age-related hypertrophy was not attributable to hemodynamic or behavioral effects of parabiosis, implicating a blood-borne factor. Using modified aptamer-based proteomics, we identified the TGF-β superfamily member GDF11 as a circulating factor in young mice that declines with age. Treatment of old mice to restore GDF11 to youthful levels recapitulated the effects of parabiosis and reversed age-related hypertrophy, revealing a therapeutic opportunity for cardiac aging.PaperFlick |
| Databáze: | OpenAIRE |
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