Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco -Lankacidinol B
| Autor: | Lingchao Cai, Yanmin Yao, Ian B. Seiple |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Stereochemistry
Proton Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Gram-Positive Bacteria Lankacidins 010402 general chemistry 01 natural sciences Article Catalysis Polyketide chemistry.chemical_compound Biosynthesis Gram-Negative Bacteria Carbon-13 Magnetic Resonance Spectroscopy Molecular Structure biology Chemistry 010405 organic chemistry Total synthesis General Chemistry General Medicine biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences Macrolides Bacteria |
| Zdroj: | Angewandte Chemie. 130:13739-13742 |
| ISSN: | 0044-8249 |
| DOI: | 10.1002/ange.201808612 |
| Popis: | Lankacidins are a group of polyketide natural products with activity against several strains of Gram-positive bacteria. We developed a route to stereochemically diverse variants of 2,18-seco-lankacidinol B and found that the stereochemical assignment at C4 requires revision. This has interesting implications for the biosynthesis of natural products of the lankacidin class, all of which possessed uniform stereochemistry prior to this finding. We have evaluated 2,18-seco-lankacidinol B and three stereochemical derivatives against a panel of pathogenic Gram-positive and Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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