Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh
| Autor: | Lara Hemeryck, Florian Hermans, Ivo Lambrichts, Annelies Bronckaers, Hugo Vankelecom |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
animal structures
QH301-705.5 EPITHELIAL ROOT SHEATH Mesenchyme Review Fibroblast growth factor MESENCHYMAL STEM-CELLS Cell and Developmental Biology Wnt DENTAL MESENCHYME stomatognathic system stem cells OF-FUNCTION MUTATIONS medicine Biology (General) tooth Sonic hedgehog Process (anatomy) sonic hedgehog (Shh) BONE MORPHOGENETIC PROTEIN WNT/BETA-CATENIN Science & Technology biology Wnt signaling pathway beta-catenin Cell Biology β-catenin PERIODONTAL-LIGAMENT Cell biology Odontogenic stomatognathic diseases medicine.anatomical_structure embryonic structures biology.protein odontogenesis Stem cell Signal transduction AUTOSOMAL-DOMINANT Life Sciences & Biomedicine ROBINOW-SYNDROME Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) Frontiers in Cell and Developmental Biology |
| ISSN: | 2296-634X |
| DOI: | 10.3389/fcell.2021.758203 |
| Popis: | Teeth play essential roles in life. Their development relies on reciprocal interactions between the ectoderm-derived dental epithelium and the underlying neural crest-originated mesenchyme. This odontogenic process serves as a prototype model for the development of ectodermal appendages. In the mouse, developing teeth go through distinct morphological phases that are tightly controlled by epithelial signaling centers. Crucial molecular regulators of odontogenesis include the evolutionarily conserved Wnt, BMP, FGF and sonic hedgehog (Shh) pathways. These signaling modules do not act on their own, but are closely intertwined during tooth development, thereby outlining the path to be taken by specific cell populations including the resident dental stem cells. Recently, pivotal Wnt-Shh interaction and feedback loops have been uncovered during odontogenesis, showing conservation in other developing ectodermal appendages. This review provides an integrated overview of the interplay between canonical Wnt and Shh throughout mouse tooth formation stages, extending from the initiation of dental placode to the fully formed adult tooth. ispartof: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY vol:09 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
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