Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans
| Autor: | Oliver Blatchford, Kristen Malloy, Mhairi C Donnelly, Karen McGowan, Lisa Jarvis, Juraj Petrik, Katrina Thom, Kenneth J. Simpson, Claire Crossan, Alison Smith-Palmer, Janice S Davidson, Pamela Gilhooly, Linda Scobie, Harry R. Dalton, Ingolfur Johannessen |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Genotype Blood Donors medicine.disease_cause Virus 03 medical and health sciences Young Adult 0302 clinical medicine Hepatitis E virus Seroepidemiologic Studies Virology Epidemiology Journal Article Medicine Seroprevalence Humans 030212 general & internal medicine Hepatitis Antibodies Viremia Phylogeny seroprevalence business.industry Hepatitis E virus (HEV) Reverse Transcriptase Polymerase Chain Reaction Incidence (epidemiology) Incidence Zoonosis Public Health Environmental and Occupational Health virus diseases zoonosis Middle Aged medicine.disease Hepatitis E 030104 developmental biology Scotland Immunoglobulin G RNA Viral epidemiology Female business Research Article |
| Zdroj: | Thom, K, Gilhooly, P, McGowan, K, Malloy, K, Jarvis, L M, Crossan, C, Scobie, L, Blatchford, O, Smith-Palmer, A, Donnelly, M C, Davidson, J S, Johannessen, I, Simpson, K J, Dalton, H R & Petrik, J 2018, ' Hepatitis E virus (HEV) in Scotland : evidence of recent increase in viral circulation in humans ', Eurosurveillance, vol. 23, no. 12 . https://doi.org/10.2807/1560-7917.ES.2018.23.12.17-00174 Eurosurveillance |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/1560-7917.ES.2018.23.12.17-00174 |
| Popis: | Background Previous studies showed low levels of circulating hepatitis E virus (HEV) in Scotland. We aimed to reassess current Scottish HEV epidemiology. Methods: Blood donor samples from five Scottish blood centres, the minipools for routine HEV screening and liver transplant recipients were tested for HEV antibodies and RNA to determine seroprevalence and viraemia. Blood donor data were compared with results from previous studies covering 2004–08. Notified laboratory-confirmed hepatitis E cases (2009-16) were extracted from national surveillance data. Viraemic samples from blood donors (2016) and chronic hepatitis E transplant patients (2014–16) were sequenced. Results: Anti-HEV IgG seroprevalence varied geographically and was highest in Edinburgh where it increased from 4.5% in 2004–08) to 9.3% in 2014–15 (p = 0.001). It was most marked in donors Conclusions: The seroprevalence, number of viraemic donors and numbers of notified laboratory-confirmed cases of HEV in Scotland have all recently increased. The causes of this change are unknown, but need further investigation. Clinicians in Scotland, particularly those caring for immunocompromised patients, should have a low threshold for testing for HEV. |
| Databáze: | OpenAIRE |
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