Angiotensin-(1-7) attenuates the negative inotropic response to acetylcholine in the heart

Autor:	Carolina Nobre Ribeiro Pontes, Sérgio Scalzo, Itamar Couto Guedes Jesus, Erika Fernandes de Jesus, Allancer Divino de Carvalho Nunes, Michelle Mendanha Mendonça, Elizabeth Pereira Mendes, Diego Basile Colugnati, Carlos Henrique Xavier, Gustavo Rodrigues Pedrino, Silvia Guatimosim, Carlos Henrique Castro
Rok vydání:	2022
Předmět:	Cellular and Molecular Neuroscience Endocrinology Physiology Angiotensin II Animals Heart Myocytes Cardiac Rats Wistar Biochemistry Myocardial Contraction Acetylcholine Rats
Zdroj:	Peptides. 158
ISSN:	1873-5169
Popis:	Previous studies have suggested that the Angiotensin-(1-7) [(Ang-(1-7)] can change cardiac function by modulating the autonomic nervous system. However, it is unknown whether the Ang-(1-7) can modulate the effect of acetylcholine (ACh) in ventricular contractility. Thus, this study aimed to investigate whether Ang-(1-7) modifies the amplitude of the cardiac cholinergic effects and if these effects are intrinsic to the heart. In anesthetized Wistar rats, Ang-(1-7) attenuated the effect of ACh in decreasing the left ventricular end-systolic pressure (LVESP), dP/dt
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9e63816961257ba883322f231565b1 https://pubmed.ncbi.nlm.nih.gov/35998722 Zobrazit plný text záznamu Full Text from ScienceDirect