Perfusion Neuroimaging Abnormalities Alone Distinguish National Football League Players from a Healthy Population

Autor: Andrew B. Newberg, Bennet Omalu, Daniel Amen, Cauligi S. Raghavendra, Cyrus A. Raji, Kristen Willeumier
Rok vydání: 2016
Předmět:
Adult
Male
cognition
0301 basic medicine
football
medicine.medical_specialty
Longitudinal study
Traumatic brain injury
Brain imaging
Neuropsychological Tests
Single-photon emission computed tomography
Audiology
NFL
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Neuroimaging
Predictive Value of Tests
Brain Injuries
Traumatic
Concussion
medicine
Humans
Longitudinal Studies
Cerebral perfusion pressure
Aged
Tomography
Emission-Computed
Single-Photon
Retirement
medicine.diagnostic_test
traumatic brain injury
General Neuroscience
Neuropsychology
Brain
General Medicine
Middle Aged
medicine.disease
Surgery
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Area Under Curve
SPECT
Predictive value of tests
concussion
Female
Geriatrics and Gerontology
Psychology
030217 neurology & neurosurgery
Research Article
Zdroj: Journal of Alzheimer's Disease
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-160207
Popis: Background: National Football League (NFL) players are exposed to multiple head collisions during their careers. Increasing awareness of the adverse long-term effects of repetitive head trauma has raised substantial concern among players, medical professionals, and the general public. Objective: To determine whether low perfusion in specific brain regions on neuroimaging can accurately separate professional football players from healthy controls. Method: A cohort of retired and current NFL players (n = 161) were recruited in a longitudinal study starting in 2009 with ongoing interval follow up. A healthy control group (n = 124) was separately recruited for comparison. Assessments included medical examinations, neuropsychological tests, and perfusion neuroimaging with single photon emission computed tomography (SPECT). Perfusion estimates of each scan were quantified using a standard atlas. We hypothesized that hypoperfusion particularly in the orbital frontal, anterior cingulate, anterior temporal, hippocampal, amygdala, insular, caudate, superior/mid occipital, and cerebellar sub-regions alone would reliably separate controls from NFL players. Cerebral perfusion differences were calculated using a one-way ANOVA and diagnostic separation was determined with discriminant and automatic linear regression predictive models. Results: NFL players showed lower cerebral perfusion on average (p
Databáze: OpenAIRE
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