Safety of ovarian preservation for premenopausal patients with FIGO stage I grade 2 and 3 endometrioid endometrial adenocarcinoma
| Autor: | Dimitrios Nasioudis, Spyridon A Mastroyannis, Emily M Ko, Ashley F Haggerty, Lori Cory, Robert L Giuntoli, Sarah H Kim, Nawar A Latif |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International Journal of Gynecologic Cancer. 32:1355-1360 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1136/ijgc-2022-003450 |
| Popis: | ObjectiveTo investigate the utilization and outcomes of ovarian preservation for premenopausal patients with International Federation of Gynecology and Obstetrics (FIGO) stage I grade 2 and 3 endometrioid endometrial carcinoma undergoing hysterectomy.MethodsThe National Cancer Database was accessed; patients aged ≤45 years diagnosed between January 2004 and December 2015 with FIGO stage I grade 2 or 3 endometrioid endometrial carcinoma, who underwent hysterectomy with or without bilateral salpingo-oophorectomy and had at least 1 month of follow-up, were identified. Overall survival was assessed following generation of Kaplan-Meier curves and compared with the log-rank test. A Cox model was constructed to control for a priori selected variables.ResultsA total of 2941 patients who met the inclusion criteria were identified; 200 (6.8%) patients did not undergo bilateral salpingo-oophorectomy. Rate of ovarian preservation was comparable between patients with grade 2 (n=163, 6.6%) and grade 3 (n=37, 7.7%) tumors (p=0.38). Patients who did not undergo bilateral salpingo-oophorectomy were younger (median 39 vs 41 years, pConclusionsFor patients with grade 2 and 3 FIGO stage I endometrioid carcinoma undergoing hysterectomy, ovarian preservation is rarely performed while no clear detrimental effect on overall survival was found. |
| Databáze: | OpenAIRE |
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