Elevated Serum Uric Acid Is Associated with Greater Bone Mineral Density and Skeletal Muscle Mass in Middle-Aged and Older Adults

Autor: Juan He, Xiao-wei Dong, Chen Wang, Hui-yuan Tian, Rui Qiu, Yu-ming Chen
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Bone density
Cross-sectional study
lcsh:Medicine
chemistry.chemical_compound
0302 clinical medicine
Absorptiometry
Photon
Elderly
Bone Density
Medicine and Health Sciences
Morphogenesis
lcsh:Science
Musculoskeletal System
Bone mineral
Multidisciplinary
Lumbar Vertebrae
Femur Neck
Muscles
Middle Aged
Muscle Differentiation
Arms
Chemistry
medicine.anatomical_structure
Quartile
Connective Tissue
Physical Sciences
Legs
Female
Anatomy
Research Article
medicine.medical_specialty
030209 endocrinology & metabolism
Lumbar vertebrae
Pelvis
03 medical and health sciences
Asian People
Internal medicine
medicine
Humans
Muscle
Skeletal
Bone
Femoral neck
Hip
business.industry
lcsh:R
Limbs (Anatomy)
Chemical Compounds
Biology and Life Sciences
Bone fracture
medicine.disease
Surgery
Uric Acid
030104 developmental biology
Endocrinology
Cross-Sectional Studies
Biological Tissue
chemistry
Skeletal Muscles
Age Groups
People and Places
Uric acid
lcsh:Q
Population Groupings
business
Acids
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0154692 (2016)
ISSN: 1932-6203
Popis: Background and objective Previous studies have suggested a positive link between serum uric acid (UA) and bone mineral density (BMD). In this study, we re-examined the association between UA and BMD and further explored whether this was mediated by skeletal muscle mass in a general Chinese population. Method This community-based cross-sectional study was conducted among 3079 (963 men and 2116 women) Chinese adults aged 40–75 years. Face-to-face interviews and laboratory analyses were performed to determine serum UA and various covariates. Dual-energy X-ray absorptiometry was used to assess the BMD and appendicular skeletal muscle mass. The skeletal muscle mass index (SMI = ASM/Height2, kg/m2) for the total limbs, arms, and legs was then calculated. Results The serum UA was graded and, in general, was significantly and positively associated with the BMD and muscle mass, after adjustment for multiple covariates in the total sample. Compared with participants in lowest quartile of UA, those participants in highest quartile showed a 2.3%(whole body), 4.1%(lumbar spine), 2.4%(total hip), and 2.0% (femoral neck) greater BMDs. The mean SMIs in the highest (vs. lowest) quartile increased by 2.7% (total), 2.5% (arm), 2.7% (leg) respectively. In addition, path analysis suggested that the favorable association between UA and BMD might be mediated by increasing SMI. Conclusion The elevated serum UA was associated with a higher BMD and a greater muscle mass in a middle-aged and elderly Chinese population and the UA-BMD association was partly mediated by muscle mass.
Databáze: OpenAIRE
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