Human-Pathogenic Kasokero Virus in Field-Collected Ticks
| Autor: | Jonathan S. Towner, Amy J. Schuh, Brian R. Amman, Ketan Patel, Tara K. Sealy, Robert Swanepoel |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Rousettus Epidemiology Bunyaviridae 030231 tropical medicine vector-borne infections bats Zoology lcsh:Medicine Biology Tick Virus ticks lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine nairoviruses Chiroptera parasitic diseases Animals Humans Uganda lcsh:RC109-216 030212 general & internal medicine Ornithodoros Phylogeny Nairovirus Host (biology) Research Argasidae lcsh:R biology.organism_classification bacterial infections and mycoses Infectious Diseases Human-Pathogenic Kasokero Virus in Field-Collected Ticks arboviruses Viruses Enzootic ecology |
| Zdroj: | Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2944-2950 (2020) Emerging Infectious Diseases |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | Kasokero virus (KASV; genus Orthonairovirus) was first isolated in 1977 at Uganda Virus Research Institute from serum collected from Rousettus aegyptiacus bats captured at Kasokero Cave, Uganda. During virus characterization studies at the institute, 4 laboratory-associated infections resulted in mild to severe disease. Although orthonairoviruses are typically associated with vertebrate and tick hosts, a tick vector of KASV never has been reported. We tested 786 Ornithodoros (Reticulinasus) faini tick pools (3,930 ticks) for KASV. The ticks were collected from a large R. aegyptiacus bat roosting site in western Uganda. We detected KASV RNA in 43 tick pools and recovered 2 infectious isolates, 1 of which was derived from host blood-depleted ticks. Our findings suggest that KASV is maintained in an enzootic transmission cycle involving O. (R.) faini ticks and R. aegyptiacus bats and has the potential for incidental virus spillover to humans. |
| Databáze: | OpenAIRE |
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