Ventral pallidum cellular and pathway specificity in drug seeking
| Autor: | Yonatan M. Kupchik, Asheeta A. Prasad |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
Neurons 0303 health sciences Basal Forebrain Cognitive Neuroscience media_common.quotation_subject Addiction Drug-Seeking Behavior Drug seeking Biology Ventral pallidum 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neuropsychology and Physiological Psychology Cellular heterogeneity Pharmaceutical Preparations Recurrence Animals Neuroscience 030217 neurology & neurosurgery 030304 developmental biology media_common |
| Zdroj: | Neuroscience and biobehavioral reviews. 131 |
| ISSN: | 1873-7528 |
| Popis: | The ventral pallidum (VP) is central to the reinforcing effects across a variety of drugs and relapse to drug seeking. Emerging studies from animal models of reinstatement reveal a complex neurobiology of the VP that contributes to different aspects of relapse to drug seeking. This review builds on classical understanding of the VP as part of the final common pathway of relapse but also discusses the properties of the VP as an independent structure. These include VP neural anatomical subregions, cellular heterogeneity, circuitry, neurotransmitters and peptides. Collectively, this review provides a current understanding of the VP from molecular to circuit level architecture that contributes to both the appetitive and aversive symptoms of drug addiction. We show the complex neurobiology of the VP in drug seeking, emphasizing its critical role in addiction, and review strategic approaches that target the VP to reduce relapse rates. |
| Databáze: | OpenAIRE |
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