Induction of 7-ethoxyresorufin-O-deethylase (EROD) activity in mice foetuses by the PCB-congener 3,3',4,4'-tetrachlorobiphenyl
| Autor: | U. Törnwall, T. Sinjari, P. O. Darnerud |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Time Factors Ratón Health Toxicology and Mutagenesis Biology Toxicology Biochemistry Mice Fetus Cytochrome P-450 Enzyme System Pregnancy Internal medicine medicine Cytochrome P-450 CYP1A1 Animals Enzyme inducer reproductive and urinary physiology Pharmacology Dose-Response Relationship Drug Transplacental Cytochrome P450 General Medicine Metabolism biology.organism_classification Polychlorinated Biphenyls Mice Inbred C57BL Endocrinology Microsoma Enzyme Induction embryonic structures biology.protein Microsome Microsomes Liver Female Oxidoreductases |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 23(2) |
| ISSN: | 0049-8254 |
| Popis: | 1. 3,3',4,4'-Tetrachlorobiphenyl (TCB) induces liver microsomal 7-ethoxyresorufin-O-deethylase (EROD) activity, and this P450 isoform, i.e. CYP 1, is involved in the metabolism of TCB. 2. TCB administered i.p. to pregnant mice (5-25 mg/kg) induced foetal as well as maternal hepatic EROD activity; in all cases the maternal induced activity was higher than the foetal activity. EROD activity of TCB-induced foetuses increased with developmental age, but decreased with the length of time after treatment. 3. Strain differences were seen; in control mice and TCB-treated dams NMRIC57BL in EROD activity, but in transplacentally TCB-treated foetuses, C57BLNMRI. EROD activity in non-pregnant control C57BL mice was higher than in pregnant ones, whereas no activity was seen in control foetuses. 4. Results indicate that TCB at a certain dose can induce foetal metabolism, but that earlier observed foetal accumulation at lower TCB doses is probably a consequence of transplacental transport of maternally-produced metabolites. |
| Databáze: | OpenAIRE |
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