Resting-state activity in high-order visual areas as a window into natural human brain activations
| Autor: | Ofer Karp, Francesca Strappini, Michal Harel, Edna Furman-Haran, Meytal Wilf, Tal Golan, Rafael Malach, Hagar Goldberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cognitive Neuroscience Stimulus (physiology) 050105 experimental psychology Correlation free viewing movie naturalistic scenes ventral occipital-temporal cortex visual cortex Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Neural Pathways medicine Humans 0501 psychology and cognitive sciences High order Visual Cortex Brain Mapping Resting state fMRI Functional connectivity 05 social sciences Brain Human brain Magnetic Resonance Imaging Visual cortex medicine.anatomical_structure Visual Perception Female Psychology Neuroscience Photic Stimulation 030217 neurology & neurosurgery |
| Popis: | A major limitation of conventional human brain research has been its basis in highly artificial laboratory experiments. Due to technical constraints, little is known about the nature of cortical activations during ecological real life. We have previously proposed the “spontaneous trait reactivation (STR)” hypothesis arguing that resting-state patterns, which emerge spontaneously in the absence of external stimulus, reflect the statistics of habitual cortical activations during real life. Therefore, these patterns can serve as a window into daily life cortical activity. A straightforward prediction of this hypothesis is that spontaneous patterns should preferentially correlate to patterns generated by naturalistic stimuli compared with artificial ones. Here we targeted high-level category-selective visual areas and tested this prediction by comparing BOLD functional connectivity patterns formed during rest to patterns formed in response to naturalistic stimuli, as well as to more artificial category-selective, dynamic stimuli. Our results revealed a significant correlation between the resting-state patterns and functional connectivity patterns generated by naturalistic stimuli. Furthermore, the correlations to naturalistic stimuli were significantly higher than those found between resting-state patterns and those generated by artificial control stimuli. These findings provide evidence of a stringent link between spontaneous patterns and the activation patterns during natural vision. |
| Databáze: | OpenAIRE |
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