Uncovering a New Cause of Obstructive Hydrocephalus Following Subarachnoid Hemorrhage: Choroidal Artery Vasospasm-Related Ependymal Cell Degeneration and Aqueductal Stenosis-First Experimental Study
| Autor: | Ümit Kepoğlu, Mehmet Dumlu Aydin, Nuriye Guzin Ozdemir, Coskun Yolas, Papatya Keles, Ayhan Kanat, Cemal Gundogdu, Nazan Aydin |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Subarachnoid hemorrhage Ependymal Cell Cerebral arteries Constriction Pathologic 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Internal medicine Ependyma Medicine Animals Vasospasm Intracranial business.industry Cerebral Aqueduct Vasospasm Organ Size Cerebral Arteries Subarachnoid Hemorrhage medicine.disease nervous system diseases Hydrocephalus Disease Models Animal Aqueductal stenosis 030220 oncology & carcinogenesis Anesthesia Cerebral aqueduct Choroid Plexus Cardiology Surgery sense organs Neurology (clinical) Rabbits business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | World neurosurgery. 90 |
| ISSN: | 1878-8769 |
| Popis: | Background Hydrocephalus is a serious complication of subarachnoid hemorrhage (SAH). Obstruction of the cerebral aqueduct may cause hydrocephalus after SAH. Although various etiologic theories have been put forward, choroidal artery vasospasm–related ependymal desquamation and subependymal basal membrane rupture as mechanisms of aqueductal stenosis have not been suggested in the literature. Methods This study was conducted on 26 hybrid rabbits. Five rabbits were placed in a control group, 5 were placed in a sham group, and the remaining rabbits ( n = 16) were placed in the SAH group. In the first 2 weeks, 5 animals in the SAH group died. The other 21 animals were decapitated after the 4-week follow-up period. Choroidal artery changes resulting from vasospasm, aqueduct volume, ependymal cell density, and Evans index values of brain ventricles were obtained and compared statistically. Results Mean aqueduct volume was 1.137 mm 3 ± 0.096, normal ependymal cell density was 4560/mm 2 ± 745, and Evans index was 0.32 ± 0.05 in control animals ( n = 5); these values were 1.247 mm 3 ± 0.112, 3568/mm 2 ± 612, and 0.34 ± 0.15 in sham animals ( n = 5); 1.676 mm 3 ± 0.123, 2923/mm 2 ± 591, and 0.43 ± 0.09 in animals without aqueductal stenosis ( n = 5); and 0.650 mm 3 ± 0.011, 1234/mm 2 ± 498, and 0.60 ± 0.18 in animals with severe aqueductal stenosis ( n = 6). The choroidal vasospasm index values were 1.160 ± 0.040 in the control group, 1.150 ± 0.175 in the sham group, 1.760 ± 0.125 in the nonstenotic group, and 2.262 ± 0.160 in the stenotic group. Aqueduct volumes, ependymal cell densities, Evans index, and choroidal artery vasospasm index values were statistically significantly different between groups ( P Conclusions Ependymal cell desquamation and subependymal basal membrane destruction related to choroidal artery vasospasm may lead to aqueductal stenosis and hydrocephalus after SAH. |
| Databáze: | OpenAIRE |
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