Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems?
| Autor: | Semih Akkaya, Ibrahim Yilmaz, Hanefi Özbek, Numan Karaaslan, Cagri Ata Mutlu, Duygu Yasar Sirin, Yener Akyuva, Mahir Mahirogullari, Savas Topuk, Mehmet Isyar |
|---|---|
| Přispěvatelé: | [Topuk, Savas] Cumhuriyet Univ, Dept Radiat Oncol, Sch Med, Sivas, Turkey -- [Akyuva, Yener] Minist Hlth, Dept Neurosurg, State Hosp, TR-59100 Tekirdag, Turkey -- [Karaaslan, Numan] Namik Kemal Univ, Sch Med, Dept Neurosurg, TR-59030 Tekirdag, Turkey -- [Mutlu, Cagri A.] Acibadem Univ, Dept Med Sci, Sch Med, TR-34752 Istanbul, Turkey -- [Yilmaz, Ibrahim] Istanbul Medipol Univ, Sch Med, Dept Med Pharmacol, TR-34810 Istanbul, Turkey -- [Isyar, Mehmet] Acibadem Hosp Grp, Dept Orthopaed & Traumatol, TR-34752 Istanbul, Turkey -- [Sirin, Duygu Yasar] Namik Kemal Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-59030 Tekirdag, Turkey -- [Akkaya, Semih] Denizli Private Hosp, Dept Orthopaed & Traumatol, TR-20070 Denizli, Turkey -- [Ozbek, Hanefi] Istanbul Medipol Univ, Dept Med Pharmacol, Sch Med, TR-34810 Istanbul, Turkey -- [Mahirogullari, Mahir] Mem Hlth Grp, Dept Orthopaed & Traumatol, TR-34758 Istanbul, Turkey, YILMAZ, Ibrahim -- 0000-0003-2003-6337, KARAARSLAN, Numan -- 0000-0001-5590-0637, Ozbek, Hanefi -- 0000-0002-8084-7855, akyuva, yener -- 0000-0001-8171-5929 |
| Rok vydání: | 2017 |
| Předmět: |
Controlled Release
0301 basic medicine Pharmaceutical Science Bone Neoplasms Cochrane Library Bioinformatics drug delivery systems 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine osteosarcoma Controlled release Animals Humans Medicine Gene Silencing Molecular Targeted Therapy RNA Small Interfering miRNA pharmacogenomics Osteosarcoma Controlled release drug business.industry Oligonucleotide Gene Transfer Techniques medicine.disease Clinical trial MicroRNAs 030104 developmental biology siRNA Delayed-Action Preparations Pharmacogenomics Drug delivery business 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Current Pharmaceutical Biotechnology. 18 |
| ISSN: | 1389-2010 0004-0770 2864-1566 |
| Popis: | WOS: 000407701900010 PubMed ID: 28641566 Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small interfering-/micro-ribonucleic acid. Methods: Without any language preference, we searched US National Library of Medicine National Institutes of Health, Embase, OVID, Cochrane Library database of clinical trials from 1843 to May 25, 2016 and traced all the references of incorporated documents. The data were evaluated using descriptive statistics and the results are shown as frequency (%). Results: We haven't encountered any drug delivery system in which Small interfering ribonucleic acid/ micro ribonucleic acid oligonucleotides were embedded successfully against osteosarcoma. There has been only one research in which hairpin-ribonucleic acid was embedded. Conclusion: It was considered that drug delivery system enabling controlled oligonucleotide release in the treatment period of osteosarcoma was not projected for the clinical use. However, it cannot be neglected that the mentioned experimental studies with regard to osteosarcoma treatment establish the basis of target therapies. The method in question looks promising regarding effective treatment of osteosarcoma in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|