Triamcinolone acetonide induces sterile endophthalmitis in patients with intermediate uveitis: A case report series
| Autor: | Ovidiu Mușat, Marius Cristian Șuță, Nicolae Constantin Balica, Simona Stanca, Diana‑Maria Dărăbuş, Iasmina Yasar, Cosmin Roșca, Olimpiu Karancsi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Triamcinolone acetonide Visual acuity genetic structures Hypopyon triamcinolone acetonide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Ophthalmology medicine vitreous haze Retina business.industry sterile endophthalmitis Retinal Articles General Medicine Intravitreal administration medicine.disease eye diseases intravitreal steroids intermediate uveitis 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Intermediate uveitis sense organs medicine.symptom business Uveitis medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Due to their anti-inflammatory, antiangiogenic and antiedematous properties, corticosteroids have been commonly used in the treatment of retinal diseases. Intravitreal administration of steroids offers the maximal drug efficacy and the lowest risk of systemic side effects. The authors report three cases of presumed sterile endophthalmitis induced by triamcinolone acetonide (TA) in three eyes with intermediate non-infectious uveitis. Each patient received a single intravitreal injection of TA of 4 mg. Because of the intense vitreous inflammatory reaction, retina examination and the optical coherence tomography could not be performed, although vitreous opacities were observed on the ocular ultrasound. The dense vitreous opacity is a defining factor, the anterior segment inflammation is mild to moderate and a hypopyon is present, which may be a sterile inflammatory reaction or the triamcinolone material itself. In cases of sterile endophthalmitis, the visual acuity increases progressively as the intraocular inflammation diminishes. Local treatment with topical antibiotics, prednisolone acetate and cycloplegic eyedrops is recommended to control the inflammatory reaction. |
| Databáze: | OpenAIRE |
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