Antidepressants attenuate both the enhanced ethanol intake and ethanol-induced anxiolytic effects in diazepam withdrawn rats
| Autor: | Victor A. Molina, María Eugenia Bertotto, Silvia G. Bustos, Irene Delia Martijena |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Elevated plus maze Time Factors Alcohol Drinking medicine.drug_class Serotonin reuptake inhibitor Drinking Anxiety Pharmacology Choice Behavior Anxiolytic Drug Administration Schedule chemistry.chemical_compound Fluoxetine Internal medicine Desipramine medicine Animals Drug Interactions Pharmacology (medical) Rats Wistar Maze Learning Biological Psychiatry chemistry.chemical_classification Analysis of Variance Diazepam Ethanol Behavior Animal Dose-Response Relationship Drug business.industry Central Nervous System Depressants Antidepressive Agents Rats Substance Withdrawal Syndrome Psychiatry and Mental health Endocrinology Anti-Anxiety Agents Neurology chemistry Neurology (clinical) business medicine.drug Tricyclic |
| Zdroj: | European Neuropsychopharmacology. 15:119-130 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2004.05.009 |
| Popis: | We have recently shown that the abrupt discontinuation of chronic diazepam (DZM) administration facilitated ethanol consumption and enhanced the anxiolytic properties of ethanol. Tricyclic antidepressants such as desipramine and the selective serotonin reuptake inhibitor fluoxetine have been shown to reduce alcohol intake in rodent models of alcoholism and in alcoholics who are depressed. In the present study, we tested whether desipramine (1.25; 2.5 and 5 mg/kg, i.p.) and fluoxetine (5 mg/kg, i.p.) treatment affect both ethanol intake in a free-choice test and the anxiolytic effect induced by ethanol in DZM withdrawn rats. Adult male Wistar rats were submitted to a chronic DZM treatment (2 mg/kg per day) or vehicle (VEH) for 21 days. Twenty-four hours after the last DZM injection, rats were subjected to a free-choice paradigm between water and increasing ethanol concentrations with or without concurrent desipramine or fluoxetine administration (ethanol concentration (v/v) was increased every 4 days as follows: 2, 4, 6, 8 and 10% for the final 8 days). Chronic treatment with desipramine (24 days, twice a day, 2.5 and 5 mg/kg, i.p.) and fluoxetine (24 days, once a day; 5 mg/kg, i.p.) significantly reduced the amount of ethanol intake in DZM withdrawn rats. Furthermore, subchronic treatments with desipramine (4 days, twice a day, 2.5 and 5 mg/kg) and fluoxetine (4 days, once a day, 5 mg/kg, i.p.) blocked the anxiolytic-like behavior in the elevated plus maze induced by ethanol (1 g/kg; i.p.) in DZM withdrawn rats at day 5 of withdrawal. The present findings suggest that desipramine and fluoxetine could be effective pharmacological tools to prevent the subsequent development of ethanol dependence in rats previously exposed to DZM withdrawal. |
| Databáze: | OpenAIRE |
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