IQ, Educational Attainment, Memory and Plasma Lipids: Associations with Apolipoprotein E Genotype in 5995 Children
| Autor: | George Davey Smith, Ian N. M. Day, Jean Golding, Aroon D. Hingorani, Amy E Taylor, Philip A. I. Guthrie, John E. Deanfield, Naveed Sattar |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Lipoproteins Intelligence Blood lipids Neuropsychological Tests Education 03 medical and health sciences chemistry.chemical_compound Apolipoproteins E Cognition 0302 clinical medicine children Gene Frequency Memory Pregnancy Surveys and Questionnaires Internal medicine Genotype medicine Humans Cognitive decline Allele Child Allele frequency cognitive function Biological Psychiatry 030304 developmental biology Genetics 0303 health sciences Intelligence quotient Cholesterol Lipids Endocrinology chemistry IQ Educational Status Female lipids (amino acids peptides and proteins) Psychology APOE 030217 neurology & neurosurgery |
| Zdroj: | Biological Psychiatry. 70:152-158 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2010.10.033 |
| Popis: | Background Apolipoprotein E ( APOE ) genotype (e2/e3/e4: rs429358 e4 allele; rs7412 e2 allele) is strongly associated with both lipid levels and Alzheimer's disease. Although there is also evidence of milder cognitive impairment in later life in carriers of the APOE e4 allele, there have been few studies investigating the impact of APOE genotype on cognitive function in children. Methods We determined APOE genotype in 5995 children from the Avon Longitudinal Study of Parents and Children and investigated associations between APOE genotype and plasma lipids (at age 9), IQ (at age 8), memory (at ages 8 and 10), and performance in school attainment tests (at ages 7, 11, and 14). Results Observed genotype group counts were consistent with Hardy–Weinberg equilibrium ( χ 2 p value=.84). There were strong relationships between APOE genotype and low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, which follow the same patterns as in adults. There was no strong evidence to suggest that APOE genotype was associated with IQ (all p values ≥ .46), memory function ( p ≥ .35), or school attainment test results ( p ≥ .28). Conclusion Although APOE genotype does have strong associations with lipid levels in childhood, there does not seem to be meaningful effects on cognitive performance, suggesting that any detrimental effects of the e4 allele on cognitive function are not important until later life. |
| Databáze: | OpenAIRE |
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