CNS injection of CCK in rats: effects on real and sham feeding and gastric emptying
| Autor: | B. D. Coleman, C. A. Baile, Mary Anne Della-Fera |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Liquid diet Physiology Central nervous system Neuropeptide Peptide hormone digestive system Sincalide Catheterization Cerebral Ventricles Eating Physiology (medical) Internal medicine medicine Animals Injections Intraventricular Cholecystokinin Dose-Response Relationship Drug Gastric emptying business.industry Stomach digestive oral and skin physiology Rats Inbred Strains Rats Sham feeding Endocrinology medicine.anatomical_structure Gastric Emptying business Injections Intraperitoneal hormones hormone substitutes and hormone antagonists |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1990.258.5.r1165 |
| Popis: | Cholecystokinin (CCK) released from the intestine during feeding may have a physiological role in satiety. There is also evidence that activation of central CCK-containing pathways is involved in the control of feeding behavior. This study was carried out to determine whether CCK-8 administered into the lateral cerebral ventricles (lv) of rats suppresses both sham feeding (SF) and real feeding (RF). Rats with lv guides and gastric cannulas ate a liquid diet with cannulas open (SF) or closed (RF) after lv (0, 0.05, 0.5 micrograms) or intraperitoneal (ip) (0, 4 micrograms/kg) injection of CCK-8. Both RF and SF were significantly decreased by ip CCK-8. RF was also decreased in a dose-related manner after lv CCK-8, but SF was not affected by lv CCK-8. Decreased feeding after ip CCK-8 may be due in part to its suppression of gastric emptying rate (GER). To determine whether central nervous system (CNS) CCK might also be involved in the control of gastric function, GER was measured after lv (0, 0.05, 0.5 micrograms) or ip (0, 4 micrograms/kg) injection of CCK-8. GER was significantly decreased after ip CCK-8, but lv CCK-8 had no effect on GER. Although both CNS and peripheral CCK peptide systems may be involved in satiety, CNS CCK appears to depend on concurrent peripheral nutrient-related stimuli in eliciting satiety. |
| Databáze: | OpenAIRE |
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