Fibroblast growth factor 10 alleviates particulate matter-induced lung injury by inhibiting the HMGB1-TLR4 pathway
| Autor: | Junjie Chen, Yiran Hu, Chen Chaolei, Lingjing Liu, Jin-San Zhang, Mingyang Zhu, Chenjian Song, Nian Dong, Chengshui Chen, Qiang Wang, Jingli Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Aging
Biopsy Gene Expression Inflammation Respiratory Mucosa Lung injury Pharmacology HMGB1 medicine Humans TLR4 HMGB1 Protein particulate matter FGF10 Lung Cell Death medicine.diagnostic_test biology Chemistry Interleukin Lung Injury Cell Biology Immunohistochemistry Toll-Like Receptor 4 stomatognathic diseases Bronchoalveolar lavage medicine.anatomical_structure inflammation Gene Knockdown Techniques biology.protein Cytokines Tumor necrosis factor alpha Disease Susceptibility medicine.symptom Fibroblast Growth Factor 10 Biomarkers Research Paper Signal Transduction |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.102676 |
| Popis: | Exposure to particulate matter (PM) is associated with increased incidence of respiratory diseases. The present study aimed to investigate the roles of fibroblast growth factor 10 (FGF10) in PM-induced lung injury. Mice were intratracheally instilled with FGF10 or phosphate-buffered saline at one hour before instillation of PM for two consecutive days. In addition, the anti-inflammatory impact of FGF10 in vitro and its effect on the high-mobility group box 1 (HMGB1)-toll-like receptor 4 (TLR4) pathway was investigated. It was found that PM exposure is associated with increased inflammatory cell infiltration into the lung and increased vascular protein leakage, while FGF10 pretreatment attenuated both of these effects. FGF10 also decreased the PM-induced expression of interleukin (IL)-6, IL-8, tumor necrosis factor-α and HMGB1 in murine bronchoalveolar lavage fluid and in the supernatants of human bronchial epithelial cells exposed to PM. FGF10 exerted anti-inflammatory and cytoprotective effects by inhibiting the HMGB1-TLR4 pathway. These results indicate that FGF10 may have therapeutic values for PM-induced lung injury. |
| Databáze: | OpenAIRE |
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