Gender-related Distribution of the Interleukin-1β and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Patients with End-stage Liver Disease
| Autor: | Pierluigi Toniutto, Carlo Fabris, S. Bignulin, Ezio Fornasiere, Annarosa Cussigh, Elisabetta Fontanini, Mario Pirisi, David J. Pinato, Sara Cmet, Rosalba Minisini, Davide Bitetto, Elisa Fumolo, Edmondo Falleti |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis medicine.drug_class medicine.medical_treatment Interleukin-1beta Immunology Minisatellite Repeats Liver transplantation Biology Polymorphism Single Nucleotide Gastroenterology Young Adult Hepatitis B Chronic Gene Frequency Liver Cirrhosis Alcoholic Internal medicine medicine Humans Immunology and Allergy Distribution (pharmacology) Genetic Predisposition to Disease Allele Promoter Regions Genetic Alleles Aged Homozygote End stage liver disease Hepatitis C Chronic Middle Aged medicine.disease Receptor antagonist Rheumatology Liver Transplantation Interleukin 1 Receptor Antagonist Protein Variable number tandem repeat Haplotypes Italy Female Liver Failure |
| Zdroj: | Inflammation. 33:251-258 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/s10753-009-9179-2 |
| Popis: | Interleukin-1 beta (IL-1 beta) genetic polymorphisms and IL-1 receptor antagonist (IL1RN) variable number tandem repeat (VNTR) seem to be related with the occurrence of chronic diseases. This study aimed to verify whether IL-1 beta -511C/T, -31T/C, +3953C/T and IL1RN VNTR were associated to the development of liver cirrhosis. Two hundred forty cirrhotic patients were involved in the study. A significant trend was detected, for increasing cirrhosis frequencies, grouping the patients as follows: females and males carrying neither the IL-1 beta (-511 -31) T-C/T-C or T-C/(T-T or C-C) diplotypes nor any IL1RN A2 allele (138/292), males carrying either the IL-1 beta T-C/T-C or T-C/(T-T or C-C) diplotypes or at least one IL1RN A2 allele (74/147) and males carrying either the IL-1 beta T-C/T-C or T-C/(T-T or C-C) diplotypes and at least one IL1RN A2 allele (28/37) (p0.01). IL-1 beta polymorphisms are associated with the occurrence of end stage liver disease. IL-1 beta inflammatory activity appears more pronounced in males. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink