Hyperpyrexia, allergic-type response and death occurring with low-dose bleomycin administration
| Autor: | Richard L. Levy, Stephen Chiarillo |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Cancer Research Skin Neoplasms Fever Premedication Bleomycin Dexamethasone Metastatic carcinoma Drug Hypersensitivity chemistry.chemical_compound Mycosis Fungoides Medicine Humans Neoplasm Metastasis Acetaminophen Aged Mycosis fungoides Dose-Response Relationship Drug business.industry Poorly differentiated Low dose General Medicine medicine.disease Oncology chemistry Anesthesia Shock (circulatory) Injections Intravenous Drug Therapy Combination medicine.symptom business |
| Zdroj: | Oncology. 37(5) |
| ISSN: | 0030-2414 |
| Popis: | This is a case report of hyperpyrexia, shock and death following initial injection of low-dose bleomycin (7.5 units) for a poorly differentiated metastatic carcinoma. Premedication with high-dose dexamethasone and acetaminophen did not abort the reaction. A review of the literature uncovered one nearly fatal reaction to a test dose of 1 unit of bleomycin All previously reported fatal cases were in patients with lymphoma who had received an initial dose of at least 25 units/m2. Since the 'safe' test dose of bleomycin is not known, test doses of 1 unit or lower should be routinely used; the effect of premedication is also unclear. |
| Databáze: | OpenAIRE |
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