Which Lymph Node Staging System Better Predicts Prognosis in Patients With Gastric Carcinoma? A Comparative Study Between 3 Different Lymph Node Classifications for Resected Gastric Cancer in a Western Tertiary Center
| Autor: | Andrés Sánchez Pernaute, Luis Ortega Medina, Cristina Díaz del Arco, Lourdes Estrada Muñoz, Ricardo García Martínez, Soledad García Gómez de Las Heras, María Jesús Fernández Aceñero |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Multivariate analysis Kaplan-Meier Estimate TNM staging system Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine medicine Humans 030212 general & internal medicine Lymph node Aged Neoplasm Staging Retrospective Studies Univariate analysis business.industry Area under the curve Univariate Cancer Retrospective cohort study Middle Aged Prognosis medicine.disease medicine.anatomical_structure ROC Curve Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Female Lymph Nodes Neoplasm Recurrence Local business |
| Zdroj: | American Journal of Clinical Oncology. 44:1-9 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/coc.0000000000000770 |
| Popis: | INTRODUCTION: Gastric cancer (GC) is an aggressive disease with high mortality rates. Lymph node (LN) staging of GC is a major source of controversy. The aim of this study is to compare the prognostic value of 3 different LN classifications for patients with resected GC: the eighth TNM staging system, lymph node ratio (LNR, ratio between positive and total LN) and a new anatomic-based classification (Choi classification). MATERIALS AND METHODS: A retrospective study of all cases of GC resected in a tertiary hospital in Spain (n=377). Clinical data were collected; histologic slides were reviewed; and univariate and multivariate analyses of disease-free survival (DFS) and overall survival (OS) were performed. RESULTS: In all, 315 patients fulfilled inclusion criteria. Univariate analysis showed that all classifications were significantly associated with tumor death and progression (P |
| Databáze: | OpenAIRE |
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