Genetic Variability Testing of Neurodevelopmental Genes in Schizophrenic Patients
| Autor: | Vita Dolžan, Tea Terzić, Matej Kastelic, Blanka Kores Plesničar |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Neuregulin-1 Population Nerve Tissue Proteins Single-nucleotide polymorphism Polymorphism Single Nucleotide Cellular and Molecular Neuroscience DISC1 Proto-Oncogene Proteins Internal medicine mental disorders medicine Humans Neuregulin 1 Receptor Notch4 education education.field_of_study Receptors Notch Positive and Negative Syndrome Scale biology Brain-Derived Neurotrophic Factor General Medicine Middle Aged medicine.disease Schizophrenia Case-Control Studies biology.protein Clinical Global Impression Female Psychology rs6265 Clinical psychology |
| Zdroj: | Journal of Molecular Neuroscience. 56:205-211 |
| ISSN: | 1559-1166 0895-8696 |
| Popis: | This study investigated the associations between single nucleotide polymorphisms in the neurodevelopmental Disrupted In Schizophrenia 1 (DISC1 ), neuregulin 1 (NRG1), brain-derived neurotrophic factor (BDNF) and NOTCH4 genes and the clinical symptoms and the occurrence of treatment-resistant schizophrenia in the Slovenian population. We included 138 schizophrenia patients, divided into treatment-responsive and treatment-resistant group and 94 healthy blood donors. All subjects were genotyped for eight polymorphisms (DISC1 rs6675281, DISC1 rs821616, NRG1 rs3735781, NRG1 rs3735782, NRG1 rs10503929, NRG1 rs3924999, BDNF rs6265, NOTCH rs367398) and investigated for associations with clinical variables. NOTCH4 rs367398 AA/AG was significantly associated with worse Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) score. NOTCH4 rs367398 was not statistically significantly associated with the occurrence of treatment-resistant schizophrenia after the correction for multiple testing. Our data indicate that NOTCH4 polymorphism can influence clinical symptoms in Slovenian patients with schizophrenia. |
| Databáze: | OpenAIRE |
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