Differences in the diagnostic value of various criteria of negative T waves for hypertrophic cardiomyopathy based on a molecular genetic diagnosis
| Autor: | Katsuharu Uchiyama, Noboru Fujino, Hiromasa Katoh, Hidekazu Ino, Tetsuo Konno, Masakazu Yamagishi, Kenshi Hayashi, Yuichiro Sakamoto, Eiichi Masuta, Toshinari Tsubokawa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Electrodiagnosis Value (computer science) Left ventricular hypertrophy Sensitivity and Specificity Electrocardiography Negative t wave Internal medicine T wave Humans Medicine cardiovascular diseases medicine.diagnostic_test business.industry Genetic Carrier Screening Hypertrophic cardiomyopathy General Medicine Cardiomyopathy Hypertrophic medicine.disease Pedigree Mutation Cardiology Female business Genetic diagnosis |
| Zdroj: | Clinical Science. 112:577-582 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs20060293 |
| Popis: | Differences in the diagnostic value of a variety of definitions of negative T waves for HCM (hypertrophic cardiomyopathy) have not yet been clarified, resulting in a number of definitions being applied in previous studies. The aim of the present study was to determine the most accurate diagnostic definition of negative T waves for HCM in genotyped populations. Electrocardiographic and echocardiographic findings were analysed in 161 genotyped subjects (97 carriers and 64 non-carriers). We applied three different criteria that have been used in previous studies: Criterion 1, negative T wave >10 mm in depth in any leads; Criterion 2, negative T wave >3 mm in depth in at least two leads; and Criterion 3, negative T wave >1 mm in depth in at least two leads. Of the three criteria, Criterion 3 had the highest sensitivity (43% compared with 5 and 26% in Criterion 1 and Criterion 2 respectively; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|