Measurement of myocardial accumulation of123I-metaiodobenzylguanidine for studying cardiac autonomic neuropathy in diabetes mellitus
| Autor: | M. Mäntysaari, Kari U. O. Tahvanainen, Esko Länsimies, Matti Uusitupa, Jyrki T. Kuikka, J. Mustonen, Esko Vanninen |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cardiac function curve medicine.medical_specialty Neurology Single-photon emission computed tomography Iodine Radioisotopes Radioligand Assay Diabetic Neuropathies Spect imaging Internal medicine Diabetes mellitus Humans Medicine Pure autonomic failure Aged Tomography Emission-Computed Single-Photon Diabetic Autonomic Neuropathy medicine.diagnostic_test Iodobenzenes Endocrine and Autonomic Systems business.industry Myocardium Heart Middle Aged medicine.disease 3-Iodobenzylguanidine Blood pressure Endocrinology Autonomic Nervous System Diseases Case-Control Studies Exercise Test Cardiology Neurology (clinical) business |
| Zdroj: | Clinical Autonomic Research. 6:163-169 |
| ISSN: | 1619-1560 0959-9851 |
| DOI: | 10.1007/bf02281904 |
| Popis: | The association of myocardial 123I-metaiodobenzylguanidine (MIBG) accumulation and autonomic neuropathy, as well as factors known to affect autonomic nervous function, were studied in a group of 12 diabetic patients representing different degrees of autonomic failure. The early myocardial uptake phase of 123I-MIBG was measured by calculating the peak net influx rate for the first 30 min after the 123I-MIBG injection and by single photon emission computed tomography (SPECT) imaging 1 h after the injection. The retainment of 123I-MIBG in the myocardium was measured using SPECT imaging 6 h after the injection, and myocardial uptake and the myocardium/liver uptake ratio were calculated. The 6-h myocardium/liver uptake ratio of 123I-MIBG was significantly (p0.05) lower in the diabetic patients with clinically evident autonomic neuropathy compared with those without autonomic neuropathy. Greater body mass index was associated with lower peak net influx rate and 1-h myocardial uptake of 123I-MIBG, and greater diastolic blood pressure was associated with lower 1-h myocardial uptake of 123I-MIBG, whether or not the patients had diabetic autonomic neuropathy. In conclusion, reduction in the 6-h myocardium/liver uptake ratio of 123I-MIBG is related to diabetic autonomic neuropathy. Because the early 123I-MIBG accumulation in myocardium is reduced in diabetic patients with greater body mass index and diastolic blood pressure, irrespective of autonomic neuropathy, our results encourage the use of the late myocardial accumulation of 123I-MIBG for studying sympathetic neuropathy in the diabetic heart. |
| Databáze: | OpenAIRE |
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