Coagulation Abnormalities following Intensive Plasma Exchange on the Cell Separator
| Autor: | Ann Chirnside, Christopher V. Prowse, S. J. Urbaniak, A. J. Keller |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Factor VIII Time Factors Plasma Exchange Chemistry Antithrombin III Cell Antithrombin Factor V Fibrinogen Hematology Factor VII Surgery Factor IX medicine.anatomical_structure Endocrinology Internal medicine Factor X medicine Humans Prothrombin Blood Coagulation medicine.drug |
| Zdroj: | British Journal of Haematology. 48:627-634 |
| ISSN: | 0007-1048 |
| Popis: | The effects of intensive plasma exchange on the circulating levels of coagulation factors I, II, V, VII, VIII, IX, X and antithrombin III were determined. During courses of daily exchange marked cumulative reductions of coagulation factors may occur, particularly in the case of factors I, II and X, although usually remaining above the levels considered adequate for haemostasis. The extent of cumulative reduction and subsequent recovery differed for patients with different diseases. While antithrombin III levels were reduced during plasma exchange the results suggest that this may be partly due to consumption as well as physical removal. The very low incidence of haemorrhagic sequelae and absence of thrombotic events following plasma exchange at this Centre is explained by the maintenance of adequate levels of coagulation factors and of antithrombin III even during courses of daily plasma exchange. |
| Databáze: | OpenAIRE |
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