Low-protein diet applied as part of combination therapy or stand-alone normalizes lifespan and tumor proliferation in a model of intestinal cancer
| Autor: | Jakob von Frieling, Judith Bossen, Alina Proske, Thomas Roeder |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Combination therapy EGFR Afatinib medicine.medical_treatment Longevity afatinib Antineoplastic Agents Targeted therapy Low-protein diet stem cells dietary protein restriction Intestinal Neoplasms Diet Protein-Restricted medicine cancer Animals Protein Kinase Inhibitors Caloric Restriction Cell Proliferation EGFR inhibitors business.industry Cancer Cell Biology medicine.disease Drosophila melanogaster Cancer research Drosophila Female Stem cell business Adjuvant Research Paper medicine.drug |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.203692 |
| Popis: | Tumors of the intestinal tract are among the most common tumor diseases in humans, but, like many other tumor entities, show an unsatisfactory prognosis with a need for effective therapies. To test whether nutritional interventions and a combination with a targeted therapy can effectively cure these cancers, we used the fruit fly Drosophila as a model. In this system, we induced tumors by EGFR overexpression in intestinal stem cells. Limiting the amount of protein in the diet restored life span to that of control animals. In combination with a specific EGFR inhibitor, all major tumor-associated phenotypes could be rescued. This form of treatment was also successful in a real treatment scenario, which means when they started after the full tumor phenotype was expressed. In conclusion, reduced protein administration can be a very promising form of adjuvant cancer therapy. |
| Databáze: | OpenAIRE |
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