Cysteine oxidation and annulment of amphotericin B inhibition of Coccidioides immitis
| Autor: | J.M. Cobb, J.E. Sippel, H. B. Levine |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Spores
Coccidioides immitis medicine.drug_class Chromatography Paper Manometry Antibiotics Cell Cystine Endospore Microbiology chemistry.chemical_compound Oxygen Consumption Amphotericin B medicine Cysteine Oxidase test biology Cell-Free System Coccidioides Cell Membrane General Medicine biology.organism_classification Infectious Diseases medicine.anatomical_structure chemistry Biochemistry Oxidoreductases Oxidation-Reduction medicine.drug |
| Zdroj: | Sabouraudia. 8(3) |
| ISSN: | 0036-2174 |
| Popis: | The capacity of cysteine to annul the inhibitory action of amphotericin B on Coccidioides immitis was studied. Concomitant with inhibited growth were suppressed respiration patterns. Added cysteine, however, which was not oxidized by untreated endospores, was attacked by amphotericin-treated cells; it was oxidized to cystine. A crude cysteine oxidase was obtained from endospores that had not been exposed to cysteine. Evidence is presented that exogeneous cysteine is oxidized by endospores only after amphotericin damages cell barriers. It is speculated that the resulting oxidation is an important feature in the annulment of amphotericin activity. |
| Databáze: | OpenAIRE |
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