Administration of histone deacetylase inhibitor during neonatal period changes emotionality of adult male 129Sv mice
| Autor: | E. A. Aleksandrova, O. V. Burenkova, I. Yu. Zaraiskaya |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Elevated plus maze Mice 129 Strain medicine.drug_class Period (gene) Pharmacology Anxiety General Biochemistry Genetics and Molecular Biology Open field Epigenesis Genetic Emotionality Internal medicine Conditioning Psychological medicine Animals Epigenetics biology Chemistry Valproic Acid Histone deacetylase inhibitor General Medicine Fear Histone Deacetylase Inhibitors Endocrinology Histone Animals Newborn Acetylation biology.protein |
| Zdroj: | Bulletin of experimental biology and medicine. 156(5) |
| ISSN: | 1573-8221 |
| Popis: | Environmental factors acting during the neonatal period affected the formation of phenotype of adult animals via epigenetic modifications of the genome, e.g. histone acetylation. We studied the effects of blockage of histone deacetylases with sodium valproate on week 1 of life on the behavioral pattern of adult male 129Sv mice. The results of behavioral tests attest to long-term changes in emotional, but not cognitive pattern of adult animals after sodium valproate administration, which manifested in increased anxiety of animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink