Plasma concentrations of interleukin-6 and abdominal aortic diameter among subjects without aortic dilatation
| Autor: | Luis H. Arroyo, Richard T. Lee, Peter Libby, Nader Rifai, Luis Eduardo Paim Rohde, Paul M. Ridker, Mark A. Creager |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Asymptomatic chemistry.chemical_compound Aortic aneurysm Aneurysm Internal medicine medicine.artery medicine Humans Serum amyloid A Aorta Abdominal Aged Serum Amyloid A Protein biology business.industry Interleukin-6 C-reactive protein Abdominal aorta Middle Aged medicine.disease Abdominal aortic aneurysm Endocrinology C-Reactive Protein chemistry Multivariate Analysis cardiovascular system Cardiology biology.protein Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 19(7) |
| ISSN: | 1079-5642 |
| Popis: | Abstract —Previous studies suggest that cytokine-induced tissue inflammation may participate in the pathogenesis of abdominal aortic aneurysms. Serum inflammatory markers may reflect arterial inflammation in asymptomatic phases of the aneurysmal disease. We studied 120 outpatients (62 men; age, 65±9 years) by ultrasound evaluation of the abdominal aorta to evaluate the association of circulating levels of interleukin-6 (IL-6) with abdominal aortic diameter in subjects with normal aortic size. Aortic diameter was measured at the infrarenal level and indexed for body surface area. Seven patients with abdominal aortic dilatation (indexed aortic diameter, >1.3 cm/m 2 ) were also identified. Plasma concentrations of IL-6, serum amyloid A (SAA), C-reactive protein (CRP), total homocysteine, and lipids were measured. Among the 113 subjects without aortic dilatation, indexed aortic diameter was positively associated with serum levels of IL-6 ( P P P =0.01). IL-6 levels increased in a stepwise fashion among dichotomized groups of aortic size (low and high aortic diameters) and peaked in patients with aortic dilatation (2.3±1.2 versus 2.7±0.9 versus 3.2±0.9 pg/mL, respectively; P for trend=0.039). None of the serum lipid measurements correlated with abdominal aortic diameter. Although CRP levels were associated with SAA levels ( r =0.60; P P =0.02), SAA ( P =0.001), and total homocysteine ( P |
| Databáze: | OpenAIRE |
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