DOES O-METHYL-DOPA PLAY A ROLE IN LEVODOPA-INDUCED DYSKINESIAS?
| Autor: | Cl. Feuerstein, M. Tanche, F. Serre, Perret J, M. Gavend, Pellat J |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Dyskinesia Drug-Induced medicine.medical_specialty Levodopa Decarboxylase inhibitor Benserazide Internal medicine otorhinolaryngologic diseases medicine Humans In patient Aged Methyl dopa business.industry Carbidopa Parkinson Disease General Medicine Middle Aged nervous system diseases Peripheral Endocrinology Neurology High plasma Female Methyldopa Neurology (clinical) business medicine.drug |
| Zdroj: | Acta Neurologica Scandinavica. 56:79-82 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.1977.tb01411.x |
| Popis: | Clinically scored levodopa-induced dyskinesias were correlated with plasma dopa and O-methyl-dopa levels determined every hour during one day in 30 Parkinsonian-treated patients. In patients treated with a combination of L-dopa and a peripheral decarboxylase inhibitor (PDI), those with dyskinesias have very high plasma O-methyl-dopa levels compared with those who have no dyskinesias. In contrast, no significantly different plasma dopa levels are found in these two subgroups of patients, leaving open the question of the possible involvement of such elevated plasma O-methyl-dopa levels in favouring dyskinesias. |
| Databáze: | OpenAIRE |
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