Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry
| Autor: | Xueyan Lu, Shuqiang Zhang, Qi Chen, Tianyao Zheng, Zhonghua Tang, Xiaorui Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Cuspidata bioactivities QH301-705.5 taxus chinensis 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Biology (General) 030304 developmental biology taxus × media 0303 health sciences General Immunology and Microbiology biology Traditional medicine General Neuroscience Taxus species Taxus × media taxus cuspidata biology.organism_classification Slow growth gas chromatography-mass spectrometry Cancer treatment Taxus Gas chromatography–mass spectrometry General Agricultural and Biological Sciences Taxus cuspidata 010606 plant biology & botany |
| Zdroj: | Open Life Sciences, Vol 16, Iss 1, Pp 287-296 (2021) |
| ISSN: | 2391-5412 |
| Popis: | Taxus species have attracted much attention for their potency in cancer treatment. However, investigating the bioactivities of Taxus species is a complex task, due to their diversity, slow growth, and endangered state. The most important Taxus species in China are Taxus chinensis (T. chinensis), Taxus cuspidata (T. cuspidata), and Taxus × media (T. media), which mainly grow in the northeastern region. This article probes deep into the differences among the leaves of T. chinensis, T. cuspidata, and T. media, with the aid of gas chromatography-mass spectrometry (GC-MS). Through GC-MS, 162 compounds were detected in the samples and found to contain 35 bioactive metabolites. On this basis, 20 metabolites with significant bioactivities (antibiotic, antioxidant, anticancer, and antiaging effects) were identified via unsupervised learning of principal component analysis and supervised learning of partial least squares-discriminant analysis. The results show that T. media has the most prominent antibiotic, antioxidant, and anticancer effects, while T. cuspidata has the most diverse and abundant metabolites that slow down aging. |
| Databáze: | OpenAIRE |
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