Enhanced Identification of Potential Pleiotropic Genetic Variants for Bone Mineral Density and Breast Cancer
| Autor: | Jirong Long, Chun-Ping Zeng, Wei-Feng Deng, Hong-Wen Deng, Jie Shen, Yu-Mei Li, Feng Liu, Xu Lin, Jonathan Greenbaum, Lan Zhang, Cheng Peng, Hui-Ling Lou, Kuan-Jui Su |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
musculoskeletal diseases Bone density Endocrinology Diabetes and Metabolism Single-nucleotide polymorphism Context (language use) Genome-wide association study Breast Neoplasms Biology Polymorphism Single Nucleotide Article 03 medical and health sciences 0302 clinical medicine Endocrinology Pleiotropy Bone Density Genetic Pleiotropy Humans Orthopedics and Sports Medicine KEGG Genetics Genetic architecture 030104 developmental biology 030220 oncology & carcinogenesis Female Genome-Wide Association Study |
| Zdroj: | Calcified tissue international. 101(5) |
| ISSN: | 1432-0827 |
| Popis: | Epidemiological and clinical evidences have shown that bone mineral density (BMD) has a close relationship with breast cancer (BC). They might potentially have a shared genetic basis. By incorporating information about these pleiotropic effects, we may be able to explore more of the traits' total heritability. We applied a recently developed conditional false discovery rate (cFDR) method to the summary statistics from two independent GWASs to identify the potential pleiotropic genetic variants for BMD and BC. By jointly analyzing two large independent GWASs of BMD and BC, we found strong pleiotropic enrichment between them and identified 102 single-nucleotide polymorphisms (SNPs) in BMD and 192 SNPs in BC with cFDR |
| Databáze: | OpenAIRE |
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