Clinical and Biochemical Influence of Prostatic Stones
| Autor: | Tomislav Sorić, Jerka Dumić, Lada Bakovic, Robert Selthofer, Mirnes Selimovic, Tatjana Šimurina |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Interleukin-1beta 030232 urology & nephrology Prostatitis Sensitivity and Specificity Severity of Illness Index Calculi 03 medical and health sciences 0302 clinical medicine Lower Urinary Tract Symptoms Lower urinary tract symptoms Prostate Semen Surveys and Questionnaires Severity of illness medicine Cytokines · Inflammation · Lower urinary tract symptoms · Prostate · Prostate stones Humans Prospective Studies Prospective cohort study Inflammation business.industry Tumor Necrosis Factor-alpha Interleukin-8 Prostatic Stone Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen medicine.anatomical_structure ROC Curve 030220 oncology & carcinogenesis Quality of Life Cytokines International Prostate Symptom Score business Rheology Biomarkers |
| Zdroj: | Urologia internationalis. 98(4) |
| ISSN: | 1423-0399 |
| Popis: | Introduction: The study aimed to explore clinical influence of prostatic stones on lower urinary tract symptoms (LUTS), seminal plasma cytokines, and serum biomarkers. Materials and Methods: A total of 70 men aged ≤50 years with LUTS divided into 2 groups: group with stones (GSt) and group without prostatic stones (GNoSt). All subjects completed the International Prostate Symptom Score (IPSS) questionnaire and National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scoring questionnaire. Pre- and post-prostate massage test and uroflowmetry were performed. The serum concentration of total prostate specific antigen (PSA), free PSA, and free/total PSA (f/t PSA) ratio, seminal concentration of cytokines interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p70, and tumor necrosis factor-alpha were measured. Results: GSt subjects had significantly more severe symptoms based on IPSS answers (p = 0.0289). All domains in NIH-CPSI scores were significantly higher in the GSt group: pain (p = 0.001), urinary symptoms (p = 0.023), quality of life (p = 0.008), and with overall (p = 0.003). GSt subjects also had significantly lower maximum urinary flow (Qmax; p = 0.011), lower f/t PSA ratio (p = 0.048), and higher concentration of IL-1β (p = 0.011) and IL-8 (p = 0.001). Conclusions: Prostatic stones may influence the severity of LUTS and the symptoms of chronic prostatitis. They might reduce Qmax rate and lead to reduction of the f/t PSA ratio and produce more severe inflammation causing increased seminal concentration of IL-1β and IL-8. |
| Databáze: | OpenAIRE |
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