Toxin-induced blood vessel inclusions caused by the chronic administration of aluminum and sodium fluoride and their implications for dementia
| Autor: | Julie A. Varner, Robert L. Isaacson, Karl F. Jensen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Nervous system
Olfactory system Pathology medicine.medical_specialty Neurotoxins Pharmacology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Fluorides Immune system History and Philosophy of Science Alzheimer Disease Sodium fluoride medicine Dementia Animals Humans Aluminum Compounds General Neuroscience Stomach Brain medicine.disease Bioavailability Rats medicine.anatomical_structure chemistry Cerebrovascular Circulation Sodium Fluoride Blood vessel |
| Zdroj: | Annals of the New York Academy of Sciences. 825 |
| ISSN: | 0077-8923 |
| Popis: | Until our knowledge of the etiology of Alzheimer's dementia, as well as related conditions involving mental impairments, is greatly extended, no line of investigation should be ignored. We believed that the possible contributions of aluminum exposure to neural impairments deserved further study. In coming to this opinion we were mindful of the work of Roberts on the neurotoxic effects of inhaled aluminum silicate' as well as the neuropathologic results reported by Per1 and his associates indicating an association of aluminum with disease-affected neurons in Alzheimer's patients.*.' The possibility that certain metals including aluminum, either alone or in combination, play a role in dementia remains a viable hypothesisP While the possibility of transport of A1 to the brain via the olfactory system, especially under conditions of a partially compromised immune system, remains a likely route of entry into the nervous system, it is not the only entry route for aluminum. A1 and other elements with toxic potential enter the nervous system through many pathways, including our food and water. Initially, we investigated the effects of low doses of aluminum given to rats through their drinking water. The entry of A1 into the circulation and the brain depends on the particular species of A1 available as well as the conditions in the stomach and the digestive tract. The bioavailability of A1 may be enhanced by its complexing with fluorine (F) to form various monomeric fluoaluminum species. Of these, AIF3 was of special interest due to its lipid solubility and ability to pass |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text