Carcinoembryonic antigen expression in stages I and II breast cancer: its relationship with clinicopathologic factors
| Autor: | Lila Ricci, Alberto S Sundblad, E.Monica Pellicer |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Pathology Antibodies Neoplasm Receptor ErbB-2 Mammary gland Estrogen receptor Breast Neoplasms Pathology and Forensic Medicine Breast cancer Carcinoembryonic antigen Internal medicine Proto-Oncogene Proteins Carcinoma Medicine Humans Lymph node Aged Neoplasm Staging biology business.industry Middle Aged medicine.disease Prognosis Immunohistochemistry Carcinoembryonic Antigen medicine.anatomical_structure Logistic Models Proto-Oncogene Proteins c-bcl-2 Lymphatic Metastasis biology.protein Female business Breast carcinoma |
| Zdroj: | Human pathology. 27(3) |
| ISSN: | 0046-8177 |
| Popis: | Carcinoembryonic antigen (CEA) has been detected by inununohistochemistry in breast carcinoma, but its relationship with prognosis is still unclear. This difficulty may be because of the great variety of antibodies used for its determination. In the present study, 271 stages I and II breast carcinomas are analyzed by immunohistochemistry, using the T84.66 antibody, a well-known highly specific CEA antibody. The results show that CEA expression was not associated with any of the clinicopathologic factors analyzed. Factors associated with disease-free survival (DFS) after univariate logistic regression analyses were tumor size smaller than 2 cm ( P = .01), lymph node free of metastases ( P = .0000), low nuclear grade ( P = .007), absence of cerbB-2 overexpression ( P = .02), and bcl-2 ( P = .005) and CEA expression ( P = .005), whereas those significantly associated with a better overall survival (OS) were tumor size smaller than 2 cm ( P = .002), lymph node free of metastases ( P = .0001), low nuclear grade ( P = .01), low histological grade ( P = .02), absence of c-erbB-2 overex pression ( P = .002) and bcl-2 expression ( P = .01). After multivariate stepwise regression analysis, lymph node free of metastases ( P = .0000), CEA expression ( P = .001), absence of c-erbB-2 overexpression ( P = .01), and bcl-2 expression ( P = .01) were found to be independent factors associated with DFS, whereas lymph node free of metastases ( P = .0000), tumor size smaller than 2 cm ( P = .0000), and absence of c-erbB-2 overexpression ( P = .004) were associated with a better OS. These results show that immunohistochemical detection of CEA with the antibody T84.66 may be useful as an additional factor in establishing breast cancer prognosis. |
| Databáze: | OpenAIRE |
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