Biological evaluation of phytoconstituents from Polygonum hydropiper
| Autor: | Babu L. Tekwani, Ranga Rao Ravu, Wei Li, Xing-Cong Li, Shabana I. Khan, Caiyun Peng, Wei Wang, Wen Bin Liu, Xiong Cai, Hong Xiao, Melissa R. Jacob, Ikhlas A. Khan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Polygonum
Stereochemistry Pinosylvin Phytochemicals Trypanosoma brucei brucei Drug Evaluation Preclinical Plant Science Microbial Sensitivity Tests Biology Trypanosoma brucei 030226 pharmacology & pharmacy 01 natural sciences Biochemistry Polygonaceae Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Antimalarials 0302 clinical medicine Chalcones Anti-Infective Agents Cardamomin IC50 Isorhamnetin Traditional medicine Molecular Structure Plant Extracts Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Antimicrobial biology.organism_classification Sitosterols Trypanocidal Agents 0104 chemical sciences PPAR gamma 010404 medicinal & biomolecular chemistry chemistry Cinnamates |
| DOI: | 10.6084/m9.figshare.4487870.v1 |
| Popis: | Fourteen compounds including vanicoside B (1), vanicoside F (2), vanicoside E (3) and 5,6-dehydrokawain (4), aniba-dimer-A (5), 6,6′-((1α,2α,3β,4β)-2,4-diphenylcyclobutane-1,3-diyl)bis(4-methoxy-2H-pyran-2-one) (6), (+)-ketopinoresinol (7), isorhamnetin (8), 3,7-dihydroxy-5,6-dimethoxy-flavone (9), isalpinin (10), cardamomin (11), pinosylvin (12), 2-desoxy-4-epi-pulchellin (13) and β-sitosterol (14) were isolated from dichloromethane-soluble portion of Polygonum hydropiper. By using Alamar blue assay, compounds 2, 7, 8, 11 and 12 were found to be active against Trypanosoma brucei with IC50 values in the range of 0.49–7.77 μg/mL. Cardamomin (11) had most significant activity against T. brucei with IC50/IC90 values of 0.49/0.81 μg/mL compared to the positive control DFMO (IC50/IC90: 3.02/8.05 μg/mL). Furthermore, in antimalarial, antimicrobial, anti-inflammatory, PPAR and cytotoxic assays, some compounds have demonstrated moderate inhibitory potentials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|