Long term follow-up of patients with recurrent ovarian cancer after Ad p53 gene replacement with SCH 58500
| Autor: | Vikas Mahavni, Richard E. Buller, Stan Petrauskas, R. Kreienberg, Dennis J. Slamon, Mark D. Pegram, Jo Ann Horowitz, Beth Y. Karlan, Ingo B Runnebaum, Mark S. Shahin |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
medicine.medical_specialty Time Factors Paclitaxel medicine.medical_treatment Population Antineoplastic Agents Gastroenterology Disease-Free Survival Adenoviridae Carboplatin Cohort Studies chemistry.chemical_compound Recurrence Internal medicine medicine Humans Dosing education Molecular Biology Survival analysis Aged Ovarian Neoplasms Chemotherapy education.field_of_study business.industry Genetic Therapy Middle Aged Genes p53 Antineoplastic Agents Phytogenic Combined Modality Therapy Surgery Regimen chemistry Cohort Molecular Medicine Female business Follow-Up Studies Cohort study |
| Zdroj: | Cancer Gene Therapy. 9:567-572 |
| ISSN: | 1476-5500 0929-1903 |
| DOI: | 10.1038/sj.cgt.7700473 |
| Popis: | Objective: We have previously reported the safety, efficient gene transfer, and favorable CA125 responses of individuals with recurrent ovarian cancer treated by p53 gene replacement with the adenoviral vector SCH 58500. The purpose of the present investigation was to evaluate the long-term follow-up of these heavily pretreated patients subsequent to SCH 58500 dosing. Methods: Patients (n=36) were treated with either single-dose SCH 58500 in the phase I study or with multiple doses (MD) of SCH 58500 over multiple cycles in combination of platinum-based chemotherapy in the phase I/II portion of the study. Five patients were initially treated in the single-dose group and re-enrolled in the MD group. The MD group was evaluated both without the re-enrolled patients as MD1 (n=19), and as MD2 (n=24), which included them. Patients who were only treated on the single-dose arm were designated as SD (n=12). Most patients received additional chemotherapy at the discretion of their physicians on completion of the trial. The current analysis is a retrospective sequential cohort survival analysis. Results: The first patient was treated in March 1997 and the last patient completed SCH 58500 in September 1998. There was no difference in age at diagnosis, Karnofsky performance status, interval between diagnosis to SCH 58500, prior cycles or regimen of chemotherapy, platinum-free interval, percent platinum refractory patients, pretreatment CA125, or largest tumor volume between groups. Both MD groups had a slightly longer chemotherapy-free interval before SCH 58500 than the SD group. Median survival of individuals who received MD SCH 58500 with chemotherapy was 12–13.0 months, compared to only 5 months for those treated with SD SCH 58500. There are 10 long-term survivors more than 20 months after MD treatment for recurrent disease compared to only 2 long-term survivors after SD SCH 58500. Conclusion: The 12- to 13.0-month median survival in a heavily pretreated population with recurrent ovarian cancer compares favorably to the 16-month median survival for individuals treated with paclitaxel at the time of initial recurrence of this disease and is more than double the 5-month survival seen with palliative radiotherapy or paclitaxel failure. These data suggest that further study of SCH58500 is clearly indicated. |
| Databáze: | OpenAIRE |
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