Biomarkers for pediatric pulmonary arterial hypertension: challenges and recommendations
| Autor: | Michael E. Yeager, Kelley L. Colvin, Ozus Lohani |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Hypertension Pulmonary Disease Vascular Remodeling High morbidity Right heart failure Cell-Derived Microparticles Natriuretic Peptide Brain Humans Medicine Child Intensive care medicine business.industry Idiopathic Pulmonary Arterial Hypertension Endothelial Cells medicine.disease Magnetic Resonance Imaging Pulmonary hypertension Peptide Fragments MicroRNAs Breath Tests Echocardiography Potential biomarkers Pediatrics Perinatology and Child Health Cytokines Treatment strategy Tomography X-Ray Computed business Atrial Natriuretic Factor Biomarkers |
| Zdroj: | Paediatric Respiratory Reviews. 16:225-231 |
| ISSN: | 1526-0542 |
| Popis: | Pediatric pulmonary arterial hypertension (PAH) is an uncommon disease that can occur in neonates, infants, and children, and is associated with high morbidity and mortality. Despite advances in treatment strategies over the last two decades, the underlying structural and functional changes to the pulmonary arterial circulation are progressive and lead eventually to right heart failure. The management of PAH in children is complex due not only to the developmental aspects but also because most evidence-based practices derive from adult PAH studies. As such, the pediatric clinician would be greatly aided by specific characteristics (biomarkers) objectively measured in children with PAH to determine appropriate clinical management. This review highlights the current state of biomarkers in pediatric PAH and looks forward to potential biomarkers, and makes several recommendations for their use and interpretation. |
| Databáze: | OpenAIRE |
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