Accumulation of liposome with Sialyl Lewis X to inflammation and tumor region: Application to in vivo bio-imaging
| Autor: | Koichi Igarashi, Hideki Minematsu, Noboru Yamazaki, Naoko Kondo, Masahiko Hirai, Kazunori Oie |
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| Rok vydání: | 2007 |
| Předmět: |
Biophysics
Oligosaccharides Arthritis Inflammation Biochemistry Fluorescence Mice chemistry.chemical_compound Lewis Blood Group Antigens In vivo medicine Animals Carcinoma Ehrlich Tumor Sialyl Lewis X Antigen Molecular Biology Fluorescent Dyes Mice Inbred BALB C Liposome technology industry and agriculture Cell Biology Carbocyanines medicine.disease Arthritis Experimental Sialyl-Lewis X chemistry Reagent Liposomes Drug delivery Female medicine.symptom |
| Zdroj: | Biochemical and Biophysical Research Communications. 353:553-558 |
| ISSN: | 0006-291X |
| Popis: | We prepared the liposome binding Sialyl Lewis X (SLX) on the surface in order to specifically and efficiently deliver substances (fluorescent materials, chemical substances, proteins, genes, etc.) to inflammation or tumor regions. The liposome with SLX (SLX-Lipo-Cy5.5), in which fluorescent substance Cy5.5 was included, was administered intravenously to arthritis or Ehrlich Ascites Tumor (EAT) bearing mouse, and the accumulation of liposome was observed using two types of in vivo fluorescent imaging equipment. The result was that the accumulation of SLX-Lipo-Cy5.5 to inflammation or tumor regions was significantly higher than the control liposome without sugar chain (Lipo-Cy5.5) at 24 and 48 h after administration. In addition, it was confirmed that this accumulation showed a shift of liposome from blood vessels to the surrounding tissues. Thus, it was proven that this liposome is useful not only as an in vivo bio-imaging reagent but also as a drug delivery system (DDS). |
| Databáze: | OpenAIRE |
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