Paroxysmal Nocturnal Hemoglobinuria Assessment by Flow Cytometric Analysis
| Autor: | D. Robert Sutherland, M. Keeney, Andrea Illingworth |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
business.industry Biochemistry (medical) Clinical Biochemistry Hemoglobinuria Paroxysmal Bone marrow failure Clone (cell biology) Disease Flow Cytometry medicine.disease Hemolysis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine hemic and lymphatic diseases Immunology medicine Paroxysmal nocturnal hemoglobinuria Humans Aplastic anemia business 030215 immunology |
| Zdroj: | Clinics in Laboratory Medicine. 37:855-867 |
| ISSN: | 0272-2712 |
| Popis: | Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon but frequently debilitating disease that, if untreated, may lead to death in up to 35% of patients within 5 years. Assessment of PNH clone size by flow cytometric analysis has increased in importance with the availability of therapeutic treatments, which prevent the hemolysis of red blood cells and, hence, the myriad symptoms that accompany the disease. This article addresses flow cytometric methodologies and highlights areas of importance in implementing testing, not only for classic PNH but also for other related bone marrow failure disorders, such as aplastic anemia and low-grade myelodysplastic syndrome. |
| Databáze: | OpenAIRE |
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